Wet-resistant flexible electronics have gained impressive attention as

underwater wearable sensors, all-weather electronic skins, and implantable

bioelectrodes. However, fabricating a stable and nonswelling hydrogel-based

electronic device used in diverse liquid media is challenging and promising for the

progress of wet-resistance electronics. Herein, a solvent-resistant and tough hydrogel

conductor is successfully prepared and exhibits fatigue resistance, antifreezing

behavior, and nonswelling and wet-adhesion performances in organic and aqueous

solutions. Moreover, the hydrogels are utilized as all-weather wearable sensors

featuring high sensitivity, reliability, and wide sensing ranges for monitoring and

distinguishing various physiological signals and human motions. Furthermore, the

hydrogel sensors can even achieve accurate and stable mechanical sensing of

pressure, bending, and stretching in diverse solvents consisting of water, chloroform,

hexane, and dodecane. It is envisioned that the solvent-resistant and antifreezing hydrogel conductor can present promising

feasibility as all-weather electronic skins, intelligent sensors in solvents, and soft robots in various harsh liquid environments.